STREPTOMYCIN AND PYRIDOMYCIN DRUG MOLECULES PROVIDE THE MOST POTENTIAL INHIBITORS AGAINST RV3871 TO CURE TUBERCULOSIS

The ESX-1 secretion system of Mycobacterium tuberculosis delivers bacterial virulence factors to host cells during infection. most abundant factor, the ESAT-6/CFP-10 dimer, is targeted for via a C-terminal signal sequence on CFP-10 that recognized by cytosolic ATPase, Rv3871. ATPase component system. ESX locus contains genes encoding conserved machinery components termed EccCb1. these core are required [70, 71]. Rv3871 cytoplasmic protein connected with Rv3870 and encoded EccCb1 gene. These proteins supply energy process. Each ATPases involved in targeting secretion. binds seven amino acid peptide CFT- 10, which complex. In this we target c-terminal region block it through multiple drugs so, cannot be activated not infection (Tuberculosis). present study have comparatively studied different inhibitory antagonist drug molecule could potential inhibit responsible supply. We 16 antagonistic molecules as shortlisted based previous studies, site molecule. KEYWORDS: Tuberculosis/Drug target/Molecular Docking/Screening antituberculosis drug.